Secondary objectives were to identify predictors of treatment outcomes across clinical subtypes; to provide information on the safety profile of paroxetine and imipramine when these drugs were given for “an extended period of time”; and to estimate the rate of relapse among patients who responded to imipramine, paroxetine, and placebo and were maintained on treatment. Study enrolment took place between April 1994 and March 1997. To this end, we used the clinical study report (SKB’s “final clinical report”), including appendices A G, which are publically available on the GSK website,9 other publically available documents,10 and the individual participant data accessed through SAS Solutions OnDemand website,11 on which GSK subsequently also posted some Study 329 documents (available only to users approved by GSK).
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